Inflammatory Response in Patients with Spontaneous Intracranial Hemorrhages

Mortality and disability rates in spontaneous intracranial hemorrhages remain high despite medical advances. In recent decades, much attention has been paid to neuroinflammation as a typical response brain damage. Inflammation plays an important role the acute chronic phases of disease. The relationship between plasma cerebrospinal fluid cytokines, well factors affecting their ratios, is currently not completely clear. objective was study inflammatory hemorrhage. Subjects Methods. 59 patients aged 18 72 years (48 ± 6) were enrolled study. Patients admitted intensive care unit after episode levels interleukins blood studied: 6, 8, 10, TNF-α, C-reactive protein, leukocytes, procalcitonin (by semi-quantitative method). fluid, following parameters evaluated: cytosis, glucose, lactate, cytokines (6, TNF-α). Blood samples collected on days 1, 2, 3, 5, 7, 9, 14, 21, 28, 35, 45. Results. Systemic developed all from first day injury. most significant formed by glial cells which confirmed hundreds thousands times higher than cytokines. Conclusion. Levels pro-inflammatory are predictors unfavorable outcome.